Updated On July 17th, 2021, By Jason Wojnar : Resident Evil never goes out of style for long. This list also does not list every weapon in Resident Evil 4. Instead, it focuses on the weapons you gather throughout the actual campaign, excluding special unlockables earned from The Mercenaries and beating the game. Knowing what weapons you want to upgrade is vital to saving money and making sure you have enough resources. Related: Mistakes Everyone Makes On Their First Playthrough Of Resident Evil 4 Though initially released on the Gamecube and eventually the PS2, modern versions are easy to access on current hardware. This list should help anybody going through the game for the first time plan ahead on what to use. Resident Evil 4has such a large arsenal, it can be hard to keep track of every weapon and decide what to use during a playthrough.